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I disse tilfellene blir cannabinoider ofte brukt i tillegg til annen medisinsk behandling, og ikke alene. De blir typisk brukt etter at en pasient ikke har hatt effekt av anbefalt behandling for disse lidelsene.Utredning og behandling ved langvarig bruk og avhengighet er beskrevet i retningslinje for behandling og rehabilitering av rusmiddelproblem